| Title | Cited By | Year |
|---|---|---|
| Monkeypox viral nucleic acids detected using both DNA and RNA extraction workflows ME Sharkey, KM Babler, BS Shukla, SM Abelson, B Alsuliman, A Amirali, ... Science of The Total Environment, 164289, 2023 | 2023 | |
| Inhibitors of the notch transcriptional activation complex kinase (“nack”) and methods for use of the same AJ Capobianco, SC Schürer, X Zhu, TT Kelley US Patent 11,649,214, 2023 | 1 | 2023 |
| Reversal of lactate and PD-1–mediated macrophage immunosuppression controls growth of PTEN/p53-deficient prostate cancer K Chaudagar, HM Hieromnimon, R Khurana, B Labadie, T Hirz, S Mei, ... Clinical Cancer Research 29 (10), 1952-1968, 2023 | 3 | 2023 |
| Inhibitors of the notch transcriptional activation complex kinase (" nack") and methods for use of the same AJ Capobianco, SC Schúrer, X Zhu, TT Kelley US Patent App. 17/929,957, 2023 | 2023 | |
| A novel chemical attack on Notch-mediated transcription by targeting the NACK ATPase G Diluvio, TT Kelley, M Lahiry, A Alvarez-Trotta, EM Kolb, E Shersher, ... Molecular Therapy-Oncolytics 28, 307-320, 2023 | 2023 | |
| Predicting COVID-19 cases using SARS-CoV-2 RNA in air, surface swab and wastewater samples HM Solo-Gabriele, S Kumar, S Abelson, J Penso, J Contreras, KM Babler, ... Science of the Total Environment 857, 159188, 2023 | 4 | 2023 |
| Degradation rates influence the ability of composite samples to represent 24-hourly means of SARS-CoV-2 and other microbiological target measures in wastewater KM Babler, ME Sharkey, S Abelson, A Amirali, A Benitez, GA Cosculluela, ... Science of The Total Environment, 161423, 2023 | 2 | 2023 |
| Pharos 2023: an integrated resource for the understudied human proteome KJ Kelleher, TK Sheils, SL Mathias, JJ Yang, VT Metzger, VB Siramshetty, ... Nucleic Acids Research 51 (D1), D1405-D1416, 2023 | 3 | 2023 |
| Cellular and molecular effects of PNCK, a non-canonical kinase target in renal cell carcinoma DJ Essegian, V Chavez, F Bustamante, SC Schürer, JR Merchan Iscience 25 (12), 105621, 2022 | 1 | 2022 |
| Tyrosine Phosphorylation of CARM1 Promotes Its Enzymatic Activity and Alters Its Target Specificity in Myeloid Neoplasms with Hyperactivated JAK2 H Itonaga, AK Mookhtiar, S Greenblatt, F Liu, C Martinez, R Grozovsky, ... Blood 140 (Supplement 1), 3021-3022, 2022 | 2022 | |
| The Cyclin-G Associated Kinase (GAK) Is a Critical Dependency for Cell-Cycle Progression in Diffuse Large B-Cell Lymphoma Associated with Deregulation of the Retinoblastoma … AD Newsam, P Kumar, OB Lightfuss, L Li, A Ghoshal, S Schürer, ... Blood 140 (Supplement 1), 2261-2262, 2022 | 2022 | |
| EPCO-14. ISOSCELES: AN INTEGRATIVE FRAMEWORK FOR THE PREDICTION OF TREATMENT RESISTANT GLIOBLASTOMA CELLS R Suter, A Jermakowicz, V Stathias, L Ruiz, M D'Antuono, S Kaeppeli, ... Neuro-oncology (Charlottesville, Va.) 24 (Supplement_7), vii118-vii118, 2022 | 2022 | |
| A multi-omic analysis of MCF10A cells provides a resource for integrative assessment of ligand-mediated molecular and phenotypic responses SM Gross, MA Dane, RL Smith, KL Devlin, IC McLean, DS Derrick, ... Communications Biology 5 (1), 1066, 2022 | 4 | 2022 |
| First detection of the Monkeypox virus using wastewater-based surveillance in Miami-Dade County ME Sharkey, KM Babler, SM Abelson, B Alsuliman, A Amirali, ... | 4 | 2022 |
| Connecting omics signatures and revealing biological mechanisms with iLINCS M Pilarczyk, M Fazel-Najafabadi, M Kouril, B Shamsaei, J Vasiliauskas, ... Nature Communications 13 (1), 4678, 2022 | 8 | 2022 |
| Tyrosine phosphorylation of CARM1 promotes its enzymatic activity and alters its target specificity H Itonaga, A Mookhtiar, S Greenblatt, F Liu, C Martinez, R Grozovsky, ... | 2022 | |
| SigCom LINCS: data and metadata search engine for a million gene expression signatures JE Evangelista, DJB Clarke, Z Xie, A Lachmann, M Jeon, K Chen, ... Nucleic acids research 50 (W1), W697-W709, 2022 | 14 | 2022 |
| Combination venetoclax and selinexor effective in relapsed refractory multiple myeloma with translocation t (11; 14) S Chaudhry, N Nguyen, R Khurana, TM Totiger, S Montoya, J Afaghani, ... Cancer Research 82 (12_Supplement), 4067-4067, 2022 | 2022 | |
| Relationships between SARS-CoV-2 in wastewater and COVID-19 clinical cases and hospitalizations, with and without normalization against indicators of human waste Q Zhan, KM Babler, ME Sharkey, A Amirali, CC Beaver, MM Boone, ... Acs Es&T Water 2 (11), 1992-2003, 2022 | 24 | 2022 |
| Comparison of electronegative filtration to magnetic bead-based concentration and V2G-qPCR to RT-qPCR for quantifying viral SARS-CoV-2 RNA from wastewater KM Babler, A Amirali, ME Sharkey, SL Williams, MM Boone, ... ACS ES&T Water 2 (11), 2004-2013, 2022 | 6 | 2022 |
| Cellular And Molecular Effects Of Understudied Kinase Pregnancy-Upregulated Non-Ubiquitous Calcium-Calmodulin Dependent Kinase (PNCK) In Renal Cell Carcinoma DJ Essegian, V Chavez, F Bustamante, SC Schürer, JR Merchan bioRxiv, 2022.05. 09.491212, 2022 | 2022 | |
| The Clinical Kinase Index (CKI): A user friendly application to prioritize kinases as prospective cancer drug targets R Khurana, SC Schürer Software Impacts 12, 100257, 2022 | 1 | 2022 |
| COVID-19 Prediction using Genomic Footprint of SARS-CoV-2 in Air, Surface Swab and Wastewater Samples HM Solo-Gabriele, S Kumar, S Abelson, J Penso, J Contreras, KM Babler, ... medRxiv, 2022 | 2 | 2022 |
| Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity Y Xiong, T Liu, T Chen, J Hansen, B Hu, Y Chen, G Jayaraman, S Schürer, ... Scientific data 9 (1), 18, 2022 | 1 | 2022 |
| Metadata record for: Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity T Liu, J Hansen, T Chen, J Goldfarb, MR Birtwistle, S Schürer, EA Sobie, ... figshare Academic Research System, 2022 | 2022 | |
| AI-assisted chemical probe discovery for the understudied calcium-calmodulin dependent kinase, PNCK D Essegian, V Chavez, R Khurshid, JR Merchan, SC Schürer bioRxiv, 2022.06. 01.494277, 2022 | 1 | 2022 |
| A multiparametric pharmacogenomic strategy for drug repositioning predicts therapeutic efficacy for glioblastoma cell lines AH Shah, R Suter, P Gudoor, TT Doucet-O’Hare, V Stathias, I Cajigas, ... Neuro-oncology advances 4 (1), vdab192, 2022 | 1 | 2022 |
| A novel strategy for combination of clofarabine and pictilisib is synergistic in gastric cancer S Khalafi, S Zhu, R Khurana, I Lohse, S Giordano, S Corso, H Al-Ali, ... Translational oncology 15 (1), 101260, 2022 | 1 | 2022 |
| A library of induced pluripotent stem cells from clinically well-characterized, diverse healthy human individuals C Schaniel, P Dhanan, B Hu, Y Xiong, T Raghunandan, DM Gonzalez, ... Stem cell reports 16 (12), 3036-3049, 2021 | 9 | 2021 |
| Lessons learned from SARS-CoV-2 measurements in wastewater ME Sharkey, N Kumar, AMA Mantero, KM Babler, MM Boone, ... Science of The Total Environment 798, 149177, 2021 | 21 | 2021 |
| EPCO-18. A MESENCHYMAL CELL POPULATION MEDIATES RESISTANCE TO AURORA KINASE INHIBITORS IN GLIOBLASTOMA R Suter, V Stathias, A Jermakowicz, H Pradhyumnan, M Affer, ... Neuro-oncology (Charlottesville, Va.) 23 (Supplement_6), vi5-vi5, 2021 | 2021 | |
| Multiscale mapping of transcriptomic signatures for cardiotoxic drugs J Hansen, Y Xiong, P Dhanan, B Hu, AS Yadaw, G Jayaraman, ... | 2021 | |
| Multiscale mapping of transcriptomic signatures for cardiotoxic drugs J Hansen, Y Xiong, P Dhanan, B Hu, AS Yadaw, G Jayaraman, ... bioRxiv, 2021.11. 02.466774, 2021 | 2021 | |
| Discovery of an eIF4A Inhibitor with a Novel Mechanism of Action CJ Zerio, TA Cunningham, AS Tulino, EA Alimusa, TM Buckley, KT Moore, ... Journal of medicinal chemistry 64 (21), 15727-15746, 2021 | 6 | 2021 |
| The genetic landscape of ocular adnexa MALT lymphoma reveals frequent aberrations in NFAT and MEF2B signaling pathways M Magistri, LE Happ, J Ramdial, XQ Lu, V Stathias, K Kunkalla, N Agarwal, ... Cancer research communications 1 (1), 1, 2021 | 4 | 2021 |
| Molecular Dynamics Simulations Identify Tractable Lead-like Phenyl-Piperazine Scaffolds as eIF4A1 ATP-competitive Inhibitors DJ Essegian, TA Cunningham, CJ Zerio, E Chapman, J Schatz, ... ACS omega 6 (38), 24432-24443, 2021 | 2 | 2021 |
| Loop-mediated isothermal amplification detection of SARS-CoV-2 and myriad other applications KJM Moore, J Cahill, G Aidelberg, R Aronoff, A Bektaş, D Bezdan, ... Journal of biomolecular techniques: JBT 32 (3), 228, 2021 | 18 | 2021 |
| A LINCS microenvironment perturbation resource for integrative assessment of ligand-mediated molecular and phenotypic responses SM Gross, MA Dane, RL Smith, K Devlin, I McLean, D Derrick, C Mills, ... bioRxiv, 2021.08. 06.455429, 2021 | 4 | 2021 |
| A proteogenomic portrait of lung squamous cell carcinoma S Satpathy, K Krug, PMJ Beltran, SR Savage, F Petralia, C Kumar-Sinha, ... Cell 184 (16), 4348-4371. e40, 2021 | 100 | 2021 |
| Targeting the Notch transcriptional activation complex with a novel PRAG1 inhibitor to attenuate reactive gliosis RA Gallo, TT Kelley, G Dvoriantchikova, SH Lang, AHM Moeyersoms, ... Investigative Ophthalmology & Visual Science 62 (8), 207-207, 2021 | 2021 | |
| Proteogenomic and metabolomic characterization of human glioblastoma LB Wang, A Karpova, MA Gritsenko, JE Kyle, S Cao, Y Li, D Rykunov, ... Cancer cell 39 (4), 509-528. e20, 2021 | 227 | 2021 |
| TCRD and Pharos 2021: mining the human proteome for disease biology TK Sheils, SL Mathias, KJ Kelleher, VB Siramshetty, DT Nguyen, ... Nucleic Acids Research 49 (D1), D1334-D1346, 2021 | 79 | 2021 |
| COVID-19 Prediction using Genomic Footprint of SARS-CoV-2 in Air, Surface Swab HM Solo-Gabriele, S Kumar, S Abelson, J Penso, J Contreras, KM Babler, ... Public Health 18 (9), 2021 | 2021 | |
| Machine and deep learning approaches for cancer drug repurposing NT Issa, V Stathias, S Schürer, S Dakshanamurthy Seminars in cancer biology 68, 132-142, 2021 | 88 | 2021 |
| Integrated proteogenomic characterization across major histological types of pediatric brain cancer F Petralia, N Tignor, B Reva, M Koptyra, S Chowdhury, D Rykunov, A Krek, ... Cell 183 (7), 1962-1985. e31, 2020 | 141 | 2020 |
| The clinical kinase index: a method to prioritize understudied kinases as drug targets for the treatment of cancer D Essegian, R Khurana, V Stathias, SC Schürer Cell Reports Medicine 1 (7), 100128, 2020 | 36 | 2020 |
| Multiplex-inhibitor bead mass spectrometry reveals differential kinome signatures in newly diagnosed and recurrent glioblastoma A Jermakowicz, AM Kurimchak, J Sarkaria, R Komotar, ME Ivan, ... bioRxiv, 2020.09. 21.306910, 2020 | 2020 | |
| piNET: a versatile web platform for downstream analysis and visualization of proteomics data B Shamsaei, S Chojnacki, M Pilarczyk, M Najafabadi, W Niu, C Chen, ... Nucleic acids research 48 (W1), W85-W93, 2020 | 20 | 2020 |
| Identification of DOT1L inhibitors by structure-based virtual screening adapted from a nucleoside-focused library GS Gibbons, A Chakraborty, SM Grigsby, AC Umeano, C Liao, ... European journal of medicinal chemistry 189, 112023, 2020 | 14 | 2020 |
| Proteomic cellular signatures of kinase inhibitor-induced cardiotoxicity: Mount Sinai DToxS LINCS Center Dataset Y Xiong, T Liu, T Chen, J Hansen, B Hu, Y Chen, G Jayaraman, S Schürer, ... bioRxiv, 2020.02. 26.966606, 2020 | 1 | 2020 |
| LINCS Data Portal 2.0: next generation access point for perturbation-response signatures V Stathias, J Turner, A Koleti, D Vidovic, D Cooper, M Fazel-Najafabadi, ... Nucleic acids research 48 (D1), D431-D439, 2020 | 102 | 2020 |
| Research techniques made simple: Molecular docking in dermatology-A foray into in silico drug discovery NT Issa, EV Badiavas, S Schürer Journal of investigative dermatology 139 (12), 2400-2408. e1, 2019 | 11 | 2019 |
| FAIRshake: toolkit to evaluate the FAIRness of research digital resources DJB Clarke, L Wang, A Jones, ML Wojciechowicz, D Torre, KM Jagodnik, ... Cell systems 9 (5), 417-421, 2019 | 36 | 2019 |
| Identification of Tractable Drug-like eIF4Al Inhibitors with Potent Anti-Tumor Activity TA Cunningham, D Essegian, S Schürer, JH Schatz Blood 134, 5760, 2019 | 2019 | |
| COMP-16. COMPREHENSIVE TRANSCRIPTOMIC ANALYSIS OF SINGLE CELLS FROM RECURRENT AND PRIMARY GLIOBLASTOMA TO PREDICT CELL-TYPE SPECIFIC THERAPEUTICS R Suter, V Stathias, A Jermakowicz, A Semonche, M Ivan, R Komotar, ... Neuro-Oncology 21 (Suppl 6), vi64, 2019 | 2019 | |
| GENE-36. INTEGRATING TRANSCRIPTOMICS AND KINOMICS IDENTIFIES SYNERGISTIC DRUG COMBINATIONS FOR GLIOBLASTOMA TREATMENT A Jermakowicz, V Stathias, R Suter, J Duncan, S Schürer, N Ayad Neuro-Oncology 21 (Suppl 6), vi105, 2019 | 2019 | |
| Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS M Pilarczyk, M Kouril, B Shamsaei, J Vasiliauskas, W Niu, N Mahi, ... BioRxiv, 826271, 2019 | 35 | 2019 |
| Notch signaling pathway inhibition in the specification of human retinal ganglion cells from induced pluripotent stem cell derived retinal organoids ZA Torres, T Kelley, S Schurer, D Pelaez Investigative Ophthalmology & Visual Science 60 (9), 3330-3330, 2019 | 2019 | |
| The dark cancer kinome-untapped opportunities for the development of novel drugs DJ Essegian, R Khurana, V Stathias, V Chavez, JR Merchan, S Schürer Cancer Research 79 (13_Supplement), 5103-5103, 2019 | 2019 | |
| FAIRshake: toolkit to evaluate the findability, accessibility, interoperability, and reusability of research digital resources DJB Clarke, L Wang, A Jones, ML Wojciechowicz, D Torre, KM Jagodnik, ... BioRxiv, 657676, 2019 | 13 | 2019 |
| Improving the utility of the Tox21 dataset by deep metadata annotations and constructing reusable benchmarked chemical reference signatures DJ Cooper, S Schürer Molecules 24 (8), 1604, 2019 | 3 | 2019 |
| OSCI: standardized stem cell ontology representation and use cases for stem cell investigation Y He, WD Duncan, DJ Cooper, J Hansen, R Iyengar, E Ong, K Walker, ... BMC bioinformatics 20, 237-247, 2019 | 6 | 2019 |
| FAIRsharing as a community approach to standards, repositories and policies SA Sansone, P McQuilton, P Rocca-Serra, A Gonzalez-Beltran, M Izzo, ... Nature biotechnology 37 (4), 358-367, 2019 | 216 | 2019 |
| Design and optimization of a first-in-class NACK inhibitor: A novel path to notch inhibition T Kelley, X Zhu, A Capobianco, S Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 257, 2019 | 2019 | |
| Novel Curcumin Inspired Bis-Chalcone Promotes Endoplasmic Reticulum Stress and Glioblastoma Neurosphere Cell Death L Sansalone, EA Veliz, NG Myrthil, V Stathias, W Walters, II Torrens, ... Cancers 11 (3), 357, 2019 | 27 | 2019 |
| Use of machine learning to identify novel, behaviorally active antagonists of the insect odorant receptor co-receptor (Orco) subunit D Kepchia, P Xu, R Terryn, A Castro, SC Schürer, WS Leal, CW Luetje Scientific reports 9 (1), 4055, 2019 | 18 | 2019 |
| DrugCentral 2018: an update O Ursu, J Holmes, CG Bologa, JJ Yang, SL Mathias, V Stathias, ... Nucleic acids research 47 (D1), D963-D970, 2019 | 110 | 2019 |
| Kinome-wide activity classification of small molecules by deep learning BK Allen, NG Ayad, SC Schürer bioRxiv, 512459, 2019 | 4 | 2019 |
| How to Develop a Drug Target Ontology: KNowledge Acquisition and Representation Methodology (KNARM) H Küçük McGinty, U Visser, S Schürer Bioinformatics and Drug Discovery, 49-69, 2019 | 2 | 2019 |
| Drug and disease signature integration identifies synergistic combinations in glioblastoma V Stathias, AM Jermakowicz, ME Maloof, M Forlin, W Walters, RK Suter, ... Nature communications 9 (1), 5315, 2018 | 71 | 2018 |
| Far away from the lamppost TI Oprea, L Jan, GL Johnson, BL Roth, A Ma’ayan, S Schürer, ... PLoS biology 16 (12), e3000067, 2018 | 11 | 2018 |
| A gene family-led meta-analysis of drug-target interactions Q Cheng, S Mehta, S Schürer 2018 IEEE International Conference on Bioinformatics and Biomedicine (BIBM …, 2018 | 1 | 2018 |
| Computational Identification of Tractable Drug-like Inhibitors of eIF4A1 D Essegian, TA Cunningham, JH Schatz, S Schurer Blood 132, 5802, 2018 | 2018 | |
| CARM1 Inhibition: Evaluation of Response and Efficacy in Acute Myeloid Leukemia AK Mookhtiar, S Greenblatt, N Man, D Karl, V Stathias, S Schurer, ... Blood 132, 2719, 2018 | 2018 | |
| Polypharmacology or promiscuity? Structural interactions of resveratrol with its bandwagon of targets U Saqib, TT Kelley, SK Panguluri, D Liu, R Savai, MS Baig, SC Schürer Frontiers in pharmacology 9, 1201, 2018 | 38 | 2018 |
| Data standards, formal ontologies and software tools to facilitate integration, classification and modeling of drug discovery data S Schurer, J Zheng, J Turner, A Koleti ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | 2018 | |
| OntoloBridge: A semi-automated ontology update request system J Turner, A Clark, H McGinty, B Bunin, S Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | 2018 | |
| SynergySeq-Integration of disease and perturbation gene expression data to prioritize synergistic drug combinations in cancer S Schurer, V Stathias, AMG Jermakowicz, N Ayad ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 256, 2018 | 2018 | |
| Sustainable data and metadata management at the BD2K-LINCS Data Coordination and Integration Center V Stathias, A Koleti, D Vidović, DJ Cooper, KM Jagodnik, R Terryn, ... Scientific data 5 (1), 1-14, 2018 | 24 | 2018 |
| CARM1 is essential for myeloid leukemogenesis but dispensable for normal hematopoiesis SM Greenblatt, N Man, PJ Hamard, T Asai, D Karl, C Martinez, D Bilbao, ... Cancer cell 33 (6), 1111-1127. e5, 2018 | 51 | 2018 |
| Unexplored therapeutic opportunities in the human genome TI Oprea, CG Bologa, S Brunak, A Campbell, GN Gan, A Gaulton, ... Nature reviews Drug discovery 17 (5), 317-332, 2018 | 298 | 2018 |
| CEDAR: semantic web technology to support open science MA Musen, SA Sansone, KH Cheung, SH Kleinstein, M Crafts, ... Companion Proceedings of the The Web Conference 2018, 427-428, 2018 | 7 | 2018 |
| The library of integrated network-based cellular signatures NIH program: system-level cataloging of human cells response to perturbations AB Keenan, SL Jenkins, KM Jagodnik, S Koplev, E He, D Torre, Z Wang, ... Cell systems 6 (1), 13-24, 2018 | 338 | 2018 |
| Data Portal for the Library of Integrated Network-based Cellular Signatures (LINCS) program: integrated access to diverse large-scale cellular perturbation response data A Koleti, R Terryn, V Stathias, C Chung, DJ Cooper, JP Turner, D Vidović, ... Nucleic acids research 46 (D1), D558-D566, 2018 | 145 | 2018 |
| Drug repositioning in glioblastoma: a pathway perspective SK Tan, A Jermakowicz, AK Mookhtiar, CB Nemeroff, SC Schürer, ... Frontiers in pharmacology, 218, 2018 | 83 | 2018 |
| Ontological representation, integration, and analysis of LINCS cell line cells and their cellular responses E Ong, J Xie, Z Ni, Q Liu, S Sarntivijai, Y Lin, D Cooper, R Terryn, ... BMC bioinformatics 18 (17), 43-53, 2017 | 13 | 2017 |
| Drug target ontology to classify and integrate drug discovery data Y Lin, S Mehta, H Küçük-McGinty, JP Turner, D Vidovic, M Forlin, A Koleti, ... Journal of biomedical semantics 8 (1), 1-16, 2017 | 58 | 2017 |
| Learning reference-enriched approach towards large scale active ontology alignment and integration Q Cheng, O Ursu, TI Oprea, S Schurer 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM …, 2017 | 1 | 2017 |
| The ontology reference model for visual selectivity analysis in drug-target interactions Q Cheng, FA Lopez, C Duran, C Camarillo, TI Oprea, S Schurer 2017 IEEE International Conference on Bioinformatics and Biomedicine (BIBM …, 2017 | 1 | 2017 |
| From flamingo dance to (desirable) drug discovery: a nature-inspired approach A Sánchez-Rodríguez, Y Pérez-Castillo, SC Schürer, O Nicolotti, ... Drug discovery today 22 (10), 1489-1502, 2017 | 24 | 2017 |
| Identification of a novel class of BRD4 inhibitors by computational screening and binding simulations BK Allen, S Mehta, SWJ Ember, JY Zhu, E Schönbrunn, NG Ayad, ... ACS omega 2 (8), 4760-4771, 2017 | 31 | 2017 |
| TIN-X: target importance and novelty explorer DC Cannon, JJ Yang, SL Mathias, O Ursu, S Mani, A Waller, SC Schürer, ... Bioinformatics 33 (16), 2601-2603, 2017 | 23 | 2017 |
| Identification of therapeutic combinations in glioblastoma using personalized gene expression networks V Stathias, M Forlin, B Allen, S Schürer, NG Ayad Cancer Research 77 (13_Supplement), 416-416, 2017 | 2017 | |
| Developing a framework for digital objects in the Big Data to Knowledge (BD2K) commons: Report from the Commons Framework Pilots workshop KM Jagodnik, S Koplev, SL Jenkins, L Ohno-Machado, B Paten, ... Journal of biomedical informatics 71, 49-57, 2017 | 28 | 2017 |
| Systemic QSAR and phenotypic virtual screening: chasing butterflies in drug discovery M Cruz-Monteagudo, S Schürer, E Tejera, Y Perez-Castillo, ... Drug discovery today 22 (7), 994-1007, 2017 | 33 | 2017 |
| Pharos: collating protein information to shed light on the druggable genome DT Nguyen, S Mathias, C Bologa, S Brunak, N Fernandez, A Gaulton, ... Nucleic acids research 45 (D1), D995-D1002, 2017 | 211 | 2017 |
| From flamingo dance to MNDS Cordeiro, E Tejera, JL Medina-Franco, M Cruz-Monteagudo | 2017 | |
| The smartAPI ecosystem for making web APIs FAIR S Dastgheib, T Whetzel, A Zaveri, C Afrasiabe, P Assis, P Availlach, ... ISWC2017, the 16e International Semantic Web Conference 1931, 1-4, 2017 | 11 | 2017 |
| smartAPI: towards a more intelligent network of Web APIs M Dumontier, S Dastgheib, T Whetzel, P Assisi, P Aviilach, K Jagodnik, ... the 25th conference on Intelligent Systems for Molecular Biology and the …, 2017 | 1 | 2017 |
| Abstract A33: Discovery of novel anti-cancer therapeutic agents for Notch activation complex kinase (NACK) targeting the Notch pathway X Zhu, Z Wang, K Jin, L Astudillo, W Zhou, J Chen, P Buchwald, ... Clinical Cancer Research 23 (1_Supplement), A33-A33, 2017 | 2017 | |
| High quality, small molecule-activity datasets for kinase research R Sharma, SC Schürer, SM Muskal F1000Research 5, Chem Inf Sci-1366, 2016 | 20 | 2016 |
| Combinatorial compound stratification based on integration of LINCS, TCGA and PubChem data V Stathias, B Allen, J Clarke, NG Ayad, S Schürer Cancer Research 76 (14_Supplement), 775-775, 2016 | 2016 | |
| High quality, small molecule-activity datasets for kinase research [version 2; referees: 2 approved] R Sharma, SC Schürer, SM Muskal Volume, 2016 | 1 | 2016 |
| research [version 3; peer review: 2 approved] R Sharma, SC Schürer, SM Muskal | 2016 | |
| research [version 1; referees: 2 approved] R Sharma, SC Schürer, SM Muskal | 2016 | |
| Identification of a novel class of BRD4 inhibitors by high-throughput computational structural biology B Allen, S Mehta, N Ayad, S Schuerer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016 | 2016 | |
| Ontologies for classifying and modeling drug discovery data S Schuerer, AY Lin, S Mehta, HK McGinty, Q Cheng, A Koleti, N Zadeh, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 251, 2016 | 2016 | |
| Community training and outreach activities of the BD2K-LINCS data coordination and integration center (DCIC) S Jenkins, S Schürer, M Medvedovic, AM Ayan F1000Research, 2016 | 2016 | |
| The Cell Line Ontology Integration and Analysis of the Knowledge of LINCS Cell Lines. E Ong, J Xie, Z Ni, Q Liu, Y Lin, V Stathias, C Chung, SC Schürer, Y He ICBO/BioCreative, 2016 | 2016 | |
| Building Concordant Ontologies for Drug Discovery. H Küçük-McGinty, S Mehta, Y Lin, N Nabizadeh, V Stathias, D Vidovic, ... ICBO/BioCreative, 2016 | 1 | 2016 |
| High quality, small molecule-activity datasets for kinase research [version 1; referees: awaiting peer review] R Sharma, SC Schürer, SM Muskal | 2016 | |
| Selective targeting of extracellular insulin-degrading enzyme by quasi-irreversible thiol-modifying inhibitors SO Abdul-Hay, TD Bannister, H Wang, MD Cameron, TR Caulfield, ... ACS chemical biology 10 (12), 2716-2724, 2015 | 24 | 2015 |
| Noribogaine is a G-protein biased κ-opioid receptor agonist EL Maillet, N Milon, MD Heghinian, J Fishback, SC Schürer, ... Neuropharmacology 99, 675-688, 2015 | 55 | 2015 |
| Large-scale computational screening identifies first in class multitarget inhibitor of EGFR kinase and BRD4 BK Allen, S Mehta, SWJ Ember, E Schonbrunn, N Ayad, SC Schürer Scientific reports 5 (1), 1-16, 2015 | 62 | 2015 |
| Discovery of small molecule insulin-degrading enzyme inhibitors H Wang, T Bannister, S Abdul-Hay, M Leissring, F Madoux, S Schurer, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 250, 2015 | 2015 | |
| Ligand-and structure-based virtual screening to discover dual EGFR and BRD4 inhibitors B Allen, S Mehta, N Ayad, S Schürer Cancer Research 75 (15_Supplement), 3690-3690, 2015 | 2 | 2015 |
| An integrated bioinformatics approach for identifying patient-specific gene networks and novel therapeutic targets in glioblastoma V Stathias, C Pastori, R Komotar, M Zhang, S Schürer, J Clarke, NG Ayad Cancer Research 75 (15_Supplement), 65-65, 2015 | 2015 | |
| Screening of cell cycle fusion proteins to identify kinase signaling networks M Trojanowsky, D Vidovic, S Simanski, C Penas, S Schurer, NG Ayad Cell Cycle 14 (8), 1274-1281, 2015 | 1 | 2015 |
| Noribogaine is a Mixed Agonist/Antagonist Opioid Ligand with Profound Functional Selectivity E Maillet, N Milon, J Fishback, S Schürer, M Heghinian, N Garamszegi, ... The FASEB Journal 29, LB505, 2015 | 2015 | |
| Using the BioAssay Ontology for analyzing high-throughput screening data L Zander Balderud, D Murray, N Larsson, U Vempati, SC Schürer, ... Journal of biomolecular screening 20 (3), 402-415, 2015 | 15 | 2015 |
| Epigenetic pathways and glioblastoma treatment: insights from signaling cascades BK Allen, V Stathias, ME Maloof, D Vidovic, EF Winterbottom, ... Journal of cellular biochemistry 116 (3), 351-363, 2015 | 20 | 2015 |
| GSK3 inhibitors stabilize Wee1 and reduce cerebellar granule cell progenitor proliferation C Penas, JK Mishra, SD Wood, SC Schürer, WR Roush, NG Ayad Cell Cycle 14 (3), 417-424, 2015 | 15 | 2015 |
| BioAssay Research Database (BARD): chemical biology and probe-development enabled by structured metadata and result types EA Howe, A de Souza, DL Lahr, S Chatwin, P Montgomery, BR Alexander, ... Nucleic acids research 43 (D1), D1163-D1170, 2015 | 24 | 2015 |
| CLO: the cell line ontology S Sarntivijai, Y Lin, Z Xiang, TF Meehan, AD Diehl, UD Vempati, ... Journal of biomedical semantics 5 (1), 1-10, 2014 | 104 | 2014 |
| DD-01LIGAND-AND STRUCTURE-BASED VIRTUAL SCREENING TO DISCOVER POLYPHARMACOLOGICAL DUAL EGFR AND BRD4 INHIBITORS B Allen, S Mehta, N Ayad, S Schürer Neuro-Oncology 16 (Suppl 5), v60, 2014 | 1 | 2014 |
| Large-scale integration of small molecule-induced genome-wide transcriptional responses, Kinome-wide binding affinities and cell-growth inhibition profiles reveal global trends … D Vidović, A Koleti, SC Schürer Frontiers in genetics 5, 342, 2014 | 84 | 2014 |
| Fast and accurate semantic annotation of bioassays exploiting a hybrid of machine learning and user confirmation AM Clark, BA Bunin, NK Litterman, SC Schürer, U Visser PeerJ 2, e524, 2014 | 25 | 2014 |
| Allosteric inhibition of the IRE1α RNase preserves cell viability and function during endoplasmic reticulum stress R Ghosh, L Wang, ES Wang, BGK Perera, A Igbaria, S Morita, K Prado, ... Cell 158 (3), 534-548, 2014 | 418 | 2014 |
| Casein kinase 1δ-dependent Wee1 protein degradation C Penas, V Ramachandran, S Simanski, C Lee, F Madoux, RJ Rahaim, ... Journal of Biological Chemistry 289 (27), 18893-18903, 2014 | 25 | 2014 |
| An overview of the challenges in designing, integrating, and delivering BARD: a public chemical-biology resource and query portal for multiple organizations, locations, and … A de Souza, JA Bittker, DL Lahr, S Brudz, S Chatwin, TI Oprea, A Waller, ... Journal of biomolecular screening 19 (5), 614-627, 2014 | 26 | 2014 |
| Evolving BioAssay Ontology (BAO): modularization, integration and applications S Abeyruwan, UD Vempati, H Küçük-McGinty, U Visser, A Koleti, A Mir, ... Journal of biomedical semantics 5 (1), 1-22, 2014 | 90 | 2014 |
| Metadata standard and data exchange specifications to describe, model, and integrate complex and diverse high-throughput screening data from the library of integrated network … UD Vempati, C Chung, C Mader, A Koleti, N Datar, D Vidović, D Wrobel, ... Journal of biomolecular screening 19 (5), 803-816, 2014 | 80 | 2014 |
| ML345, a small-molecule inhibitor of the insulin-degrading enzyme (IDE) TD Bannister, H Wang, SO Abdul-Hay, A Masson, F Madoux, J Ferguson, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2014 | 15 | 2014 |
| Metadata Standard and Data Exchange Specifications to Describe, Model, and Integrate Complex and JL Muhlich, G Berriz, CH Benes, A Subramanian, A Pillai, CE Shamu, ... Journal of Biomolecular Screening 1, 14, 2014 | 2014 | |
| Uma D. Vempati1, Caty Chung1, Chris Mader1, Amar Koleti1, Nakul Datar1, Dušica Vidovic, David Wrobel2, Sean Erickson2, Jeremy L. Muhlich3, Gabriel Berriz3, Cyril H. Benes4 … D Vidovic, D Wrobel, S Erickson, JL Muhlich, G Berriz, CH Benes, ... Journal of Biomolecular Screening 1, 14, 2014 | 2014 | |
| GPCR ontology: development and application of a G protein-coupled receptor pharmacology knowledge framework MJ Przydzial, B Bhhatarai, A Koleti, U Vempati, SC Schürer Bioinformatics 29 (24), 3211-3219, 2013 | 41 | 2013 |
| Data curation and formal BioAssay Ontology (BAO)-based annotations of the DrugMatrix enable bioactivity-based target-relationship analysis and demonstrate incorporation of … T Oprea, S Schurer, A Mir, U Vempati, J Yang, O Ursu, C Bologa ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 246, 2013 | 2013 | |
| Semantic annotation of PubChem databases G Fu, C Batchelor, M Dumontier, J Hastings, H Kuecuek, SC Schurer, ... | 2013 | |
| A sphingosine 1-phosphate receptor 2 selective allosteric agonist H Satsu, MT Schaeffer, M Guerrero, A Saldana, C Eberhart, P Hodder, ... Bioorganic & medicinal chemistry 21 (17), 5373-5382, 2013 | 58 | 2013 |
| Development of highly selective casein kinase 1δ/1ε (CK1δ/ε) inhibitors with potent antiproliferative properties M Bibian, RJ Rahaim, JY Choi, Y Noguchi, S Schürer, W Chen, ... Bioorganic & medicinal chemistry letters 23 (15), 4374-4380, 2013 | 78 | 2013 |
| A chemical proteomics approach to profiling the ATP-binding proteome of Mycobacterium tuberculosis LM Wolfe, U Veeraraghavan, S Idicula-Thomas, S Schuerer, ... Molecular & cellular proteomics 12 (6), 1644-1660, 2013 | 48 | 2013 |
| Chemical interrogation of the neuronal kinome using a primary cell-based screening assay H Al-Ali, SC Schürer, VP Lemmon, JL Bixby ACS chemical biology 8 (5), 1027-1036, 2013 | 38 | 2013 |
| BioAssay Research Database: A platform to support the collection, management, and analysis of chemical biology data R Guha, D Lahr, J Bittker, TDY Chung, M Southern, S Chatwin, JJ Yang, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 245, 2013 | 2013 | |
| ML328: a novel dual inhibitor of bacterial AddAB and RecBCD helicase-nuclease DNA repair enzymes TD Bannister, R Nair, T Spicer, VF Vega, C Eberhart, BA Mercer, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2013 | 4 | 2013 |
| Identification of small molecule inhibitors of Wee1 degradation and mitotic entry S Simanski, F Madoux, RJ Rahaim, P Chase, S Schurer, M Cameron, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2013 | 3 | 2013 |
| Potent anti-diabetic actions of a novel non-agonist PPARγ ligand that blocks Cdk5-mediated phosphorylation TM Kamenecka, SA Busby, N Kumar, JH Choi, AS Banks, D Vidovic, ... Probe Reports from the NIH Molecular Libraries Program [Internet], 2013 | 15 | 2013 |
| Kinome-wide activity modeling from diverse public high-quality data sets SC Schürer, SM Muskal Journal of chemical information and modeling 53 (1), 27-38, 2013 | 55 | 2013 |
| PrOntoLearn: unsupervised lexico-semantic ontology generation using probabilistic methods S Abeyruwan, U Visser, V Lemmon, S Schürer Uncertainty Reasoning for the Semantic Web II: International Workshops URSW …, 2013 | 6 | 2013 |
| Development of highly selective casein kinase 1d/1e (CK1d/e) inhibitors with potent antiproliferative properties M Bibian, RJ Rahaim, JY Choi, Y Noguchi, S Schürer, W Chen, ... Bioorg Med Chem Lett 23 (15), 4374-4380, 2013 | 9 | 2013 |
| Tu1894 Ultrahigh-Throughput Screening Strategies for Identification of Small-Molecule Compounds That Target the Colon Cancer Oncogene KrüPpel-Like Factor 5 A Bialkowska, ML Crisp, TD Bannister, Y He, S Chowdhury, S Schürer, ... Gastroenterology (New York, NY 1943) 144 (5), S-874-S-874, 2013 | 2013 | |
| Novel Selective Allosteric and Bitopic Ligands for the S1P3 Receptor E Jo, B Bhhatarai, E Repetto, M Guerrero, S Riley, SJ Brown, Y Kohno, ... ACS chemical biology 7 (12), 1975-1983, 2012 | 60 | 2012 |
| Novel kinase inhibitors by reshuffling ligand functionalities across the human kinome D Vidović, SM Muskal, SC Schürer Journal of chemical information and modeling 52 (12), 3107-3115, 2012 | 5 | 2012 |
| Divergent allosteric control of the IRE1α endoribonuclease using kinase inhibitors L Wang, BGK Perera, SB Hari, B Bhhatarai, BJ Backes, MA Seeliger, ... Nature chemical biology 8 (12), 982-989, 2012 | 213 | 2012 |
| Formalization, annotation and analysis of diverse drug and probe screening assay datasets using the BioAssay Ontology (BAO) UD Vempati, MJ Przydzial, C Chung, S Abeyruwan, A Mir, K Sakurai, ... PloS one 7 (11), e49198, 2012 | 65 | 2012 |
| Computer Aided Drug Design & QSAR SM Muskal, SC Schurer | 2012 | |
| Knowledge-based characterization of chemistry space and visualization B Bhhatarai, S Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 244, 2012 | 2012 | |
| Exploratory computational assessment of possible binding modes for small molecule inhibitors of the CD40–CD154 co-stimulatory interaction L Ganesan, D Vidović, SC Schürer, P Buchwald Die Pharmazie-An International Journal of Pharmaceutical Sciences 67 (5 …, 2012 | 7 | 2012 |
| Crystal structure of a lipid G protein–coupled receptor MA Hanson, CB Roth, E Jo, MT Griffith, FL Scott, G Reinhart, H Desale, ... Science 335 (6070), 851-855, 2012 | 774 | 2012 |
| Compound Profiling with High-Content Screening Methodology T Mayer, S Schurer Chemical Genomics, 215, 2012 | 2012 | |
| Allosteric control of the IRE1 alpha endoribonuclease using kinase inhibitors. L Wang, G Perera, S Hari, B Bhhatarai, B Backes, M Seeliger, S Schurer, ... MOLECULAR BIOLOGY OF THE CELL 23, 2012 | 2012 | |
| Development and Applications of the Bioassay Ontology (BAO) to Describe and Categorize High-Throughput Assays UD Vempati, SC Schürer Eli Lilly & Company and the National Center for Advancing Translational …, 2012 | 6 | 2012 |
| Discovery and optimization of indoles and 7-azaindoles as Rho kinase (ROCK) inhibitors (part-I) S Chowdhury, EH Sessions, JR Pocas, W Grant, T Schröter, L Lin, C Ruiz, ... Bioorganic & medicinal chemistry letters 21 (23), 7107-7112, 2011 | 39 | 2011 |
| BioAssay Ontology (BAO): a semantic description of bioassays and high-throughput screening results U Visser, S Abeyruwan, U Vempati, RP Smith, V Lemmon, SC Schürer BMC bioinformatics 12 (1), 1-16, 2011 | 132 | 2011 |
| Identification of Small-Molecule Inhibitors of the Colorectal Cancer Oncogene Krüppel-like Factor 5 Expression by Ultrahigh-Throughput ScreeninguHTS for KLF5 Inhibitors AB Bialkowska, M Crisp, T Bannister, Y He, S Chowdhury, S Schürer, ... Molecular cancer therapeutics 10 (11), 2043-2051, 2011 | 52 | 2011 |
| Antidiabetic actions of a non-agonist PPARγ ligand blocking Cdk5-mediated phosphorylation JH Choi, AS Banks, TM Kamenecka, SA Busby, MJ Chalmers, N Kumar, ... Nature 477 (7365), 477-481, 2011 | 555 | 2011 |
| Small molecule–mediated activation of the integrin CD11b/CD18 reduces inflammatory disease D Maiguel, MH Faridi, C Wei, Y Kuwano, KM Balla, D Hernandez, ... Science signaling 4 (189), ra57-ra57, 2011 | 130 | 2011 |
| Distinct functional and conformational states of the human lymphoid tyrosine phosphatase catalytic domain can be targeted by choice of the inhibitor chemotype D Vidović, Y Xie, A Rinderspacher, SX Deng, DW Landry, C Chung, ... Journal of computer-aided molecular design 25, 873-883, 2011 | 2 | 2011 |
| SMARTNames: a new framework to organize chemical structural information based on chemically relevant functional groups B Bhhatarai, S Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 242, 2011 | 2 | 2011 |
| Cell Line Ontology: Redesigning the Cell Line Knowledgebase to Aid Integrative Translational Informatics. S Sarntivijai, Z Xiang, TF Meehan, AD Diehl, U Vempati, SC Schürer, ... ICBO 833, 25-32, 2011 | 22 | 2011 |
| Computational modeling of substrate specificity and catalysis of the β-secretase (BACE1) enzyme A Barman, S Schürer, R Prabhakar Biochemistry 50 (20), 4337-4349, 2011 | 57 | 2011 |
| Current and Future Challenges for Collaborative Computational Technologies for the Life Sciences AJ Williams, RJG Arnold, C Neylon, RW Spencer, S Schürer, S Ekins Collaborative computational technologies for biomedical research, 491-518, 2011 | 6 | 2011 |
| Suppression of TH17 differentiation and autoimmunity by a synthetic ROR ligand LA Solt, N Kumar, P Nuhant, Y Wang, JL Lauer, J Liu, MA Istrate, ... Nature 472 (7344), 491-494, 2011 | 543 | 2011 |
| Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors DA Bachovchin, JT Mohr, AE Speers, C Wang, JM Berlin, TP Spicer, ... Proceedings of the National Academy of Sciences 108 (17), 6811-6816, 2011 | 114 | 2011 |
| Organic Synthesis Toward Small-Molecule Probes and Drugs Special Feature: Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase … DA Bachovchin, JT Mohr, AE Speers, C Wang, JM Berlin, TP Spicer, ... Proceedings of the National Academy of Science 108 (17), 6811-6816, 2011 | 5 | 2011 |
| BioAssay ontology annotations facilitate cross-analysis of diverse high-throughput screening data sets SC Schürer, U Vempati, R Smith, M Southern, V Lemmon Journal of biomolecular screening 16 (4), 415-426, 2011 | 62 | 2011 |
| Small molecule inhibitors of Wee1 degradation and mitotic entry F Madoux, J Mishra, BA Mercer, N Ayad, W Roush, P Hodder, HR Rosen Probe Reports from the NIH Molecular Libraries Program [Internet], 2011 | 4 | 2011 |
| Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids T Vang, Y Xie, WH Liu, D Vidović, Y Liu, S Wu, DH Smith, ... Journal of medicinal chemistry 54 (2), 562-571, 2011 | 37 | 2011 |
| A Combined Ligand‐and Structure‐Based Virtual Screening Protocol Identifies Submicromolar PPARγ Partial Agonists D Vidović, SA Busby, PR Griffin, SC Schürer ChemMedChem 6 (1), 94-103, 2011 | 51 | 2011 |
| Bioassay Ontology to Describe High-Throughput Screening Assays and their Results. U Vempati, U Visser, S Abeyruwan, K Sakurai, M Przydzial, C Chung, ... ICBO, 2011 | 2 | 2011 |
| Tetrahydroisoquinoline derivatives as highly selective and potent Rho kinase inhibitors X Fang, Y Yin, YT Chen, L Yao, B Wang, MD Cameron, L Lin, S Khan, ... Journal of medicinal chemistry 53 (15), 5727-5737, 2010 | 66 | 2010 |
| Discovery of potent and selective urea-based ROCK inhibitors and their effects on intraocular pressure in rats Y Yin, MD Cameron, L Lin, S Khan, T Schröter, W Grant, J Pocas, ... ACS medicinal chemistry letters 1 (4), 175-179, 2010 | 39 | 2010 |
| Identification of the putative drug binding site for novel agonists of the integrin CD11b/CD18 DG Stoub, V Gupta, M Faridi, D Maiguel, C Barth, S Schurer The FASEB Journal 24, 527.5-527.5, 2010 | 2010 | |
| High-throughput screening based identification of small molecule antagonists of integrin CD11b/CD18 ligand binding MH Faridi, D Maiguel, BT Brown, E Suyama, CJ Barth, M Hedrick, ... Biochemical and biophysical research communications 394 (1), 194-199, 2010 | 12 | 2010 |
| Phenotypic profiling of bioactive libraries using primary neurons O Gutierrez Arenas, H Ali-Ali, S Schuerer, J Bixby, V Lemmon Cold Spring Harbour Meeting on Automated Imaging and High-throughput Phenotyping, 2010 | 2010 | |
| BAOSearch: a semantic web application for biological screening and drug discovery research S Abeyruwan, C Chung, N Datar, F Gayanilo, A Koleti, V Lemmon, ... Semantic Web Challenge, 9th International Semantic Web Conference (ISWC …, 2010 | 4 | 2010 |
| PrOntoLearn: unsupervised lexico-semantic ontology generation using probabilistic methods S Abeyruwan University of Miami, 2010 | 8 | 2010 |
| 14 Screening Informatics SC Schürer, NF Tsinoremas A Practical Guide to Assay Development and High-Throughput Screening in Drug …, 2009 | 3 | 2009 |
| Identification of novel agonists of the integrin CD11b/CD18 MH Faridi, D Maiguel, CJ Barth, D Stoub, R Day, S Schürer, V Gupta Bioorganic & medicinal chemistry letters 19 (24), 6902-6906, 2009 | 29 | 2009 |
| Benzothiazoles as Rho-associated kinase (ROCK-II) inhibitors Y Yin, L Lin, C Ruiz, MD Cameron, J Pocas, W Grant, T Schröter, W Chen, ... Bioorganic & medicinal chemistry letters 19 (23), 6686-6690, 2009 | 49 | 2009 |
| Knowledge-Based Characterization of Similarity Relationships in the Human Protein− Tyrosine Phosphatase Family for Rational Inhibitor Design D Vidovic, SC Schürer Journal of medicinal chemistry 52 (21), 6649-6659, 2009 | 16 | 2009 |
| Discovery of potent non-urea inhibitors of soluble epoxide hydrolase Y Xie, Y Liu, G Gong, DH Smith, F Yan, A Rinderspacher, Y Feng, Z Zhu, ... Bioorganic & medicinal chemistry letters 19 (8), 2354-2359, 2009 | 33 | 2009 |
| Potent inhibitors of Huntingtin protein aggregation in a cell-based assay A Rinderspacher, ML Cremona, Y Liu, SX Deng, Y Xie, G Gong, N Aulner, ... Bioorganic & medicinal chemistry letters 19 (6), 1715-1717, 2009 | 16 | 2009 |
| Discovery of novel small molecule cell type-specific enhancers of NF-κB nuclear translocation G Gong, Y Xie, Y Liu, A Rinderspacher, SX Deng, Y Feng, Z Zhu, Y Tang, ... Bioorganic & medicinal chemistry letters 19 (4), 1191-1194, 2009 | 8 | 2009 |
| Kinome-wide comparison of small molecule activity predictorsfrom diverse high-quality data S Schürer, R Sharma, SM Muskal CICSJ bulletin 27 (4), 87-87, 2009 | 2009 | |
| Benzimidazole-and benzoxazole-based inhibitors of Rho kinase EH Sessions, Y Yin, TD Bannister, A Weiser, E Griffin, J Pocas, ... Bioorganic & medicinal chemistry letters 18 (24), 6390-6393, 2008 | 100 | 2008 |
| Chroman-3-amides as potent Rho kinase inhibitors YT Chen, TD Bannister, A Weiser, E Griffin, L Lin, C Ruiz, MD Cameron, ... Bioorganic & medicinal chemistry letters 18 (24), 6406-6409, 2008 | 55 | 2008 |
| Discovery of substituted 4-(pyrazol-4-yl)-phenylbenzodioxane-2-carboxamides as potent and highly selective Rho kinase (ROCK-II) inhibitors Y Feng, Y Yin, A Weiser, E Griffin, MD Cameron, L Lin, C Ruiz, ... Journal of medicinal chemistry 51 (21), 6642-6645, 2008 | 95 | 2008 |
| COMP 26-Exercising receptor-site similarity: From off-target identification to scaffold hopping SM Muskal, SC Schurer, J Danzer, K Hambly ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 236, 2008 | 2008 | |
| COMP 48-Surveying ligand-and target-based similarities within the Kinome SC Schurer, K Hambly, J Danzer, SM Muskal ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 236, 2008 | 2008 | |
| Ligand-Binding Pocket Shape Differences between Sphingosine 1-Phosphate (S1P) Receptors S1P1 and S1P3 Determine Efficiency of Chemical Probe … SC Schürer, SJ Brown, PJ Gonzalez-Cabrera, MT Schaeffer, ... ACS chemical biology 3 (8), 486-498, 2008 | 71 | 2008 |
| Ligand-binding pocket shape differences between S1P1 and S1P3 determine efficiency of chemical probe identification by uHTS SC Schürer, SJ Brown, PG Cabrera, MT Schaeffer, J Chapman, E Jo, ... ACS chemical biology 3 (8), 486, 2008 | 2 | 2008 |
| Utilizing high throughput screening data for predictive toxicology models: protocols and application to MLSCN assays R Guha, SC Schürer Journal of computer-aided molecular design 22, 367-384, 2008 | 52 | 2008 |
| Discovery of a novel submicromolar inhibitor of the lymphoid specific tyrosine phosphatase Y Xie, Y Liu, G Gong, A Rinderspacher, SX Deng, DH Smith, U Toebben, ... Bioorganic & medicinal chemistry letters 18 (9), 2840-2844, 2008 | 46 | 2008 |
| MEDI 262-Aggregation and clearance of mutant huntingtin protein A Rinderspacher, Y Liu, SX Deng, G Gong, Y Xie, ML Cremona, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235, 2008 | 2008 | |
| MEDI 91-A nonclassical NF-kappa B pathway in HUVEC cells revealed by small molecule probes Y Liu, G Gong, Y Xie, A Rinderspacher, SX Deng, DW Landry, M Wyler, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235, 2008 | 2008 | |
| MEDI 92-Discovery of novel small molecule activators of NFkB pathway G Gong, Y Xie, Y Liu, A Rinderspacher, SX Deng, DW Landry, M Wyler, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235, 2008 | 2008 | |
| MEDI 241-Identification of small molecular inhibitors of lymphocyte specific protein tyrosine phosphatase Y Xie, Y Liu, G Gong, A Rinderspacher, SX Deng, DW Landry, DH Smith, ... ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 235, 2008 | 2008 | |
| Introducing our Authors N Thorne, SC Schurer, SJ Brown, HL Schultheisz ACS Chemical Biology 3 (8), 453-453, 2008 | 2008 | |
| Identification of N-(quinolin-8-yl) benzenesulfonamides as agents capable of down-regulating NFκB activity within two separate high-throughput screens of NFκB activation Y Xie, SX Deng, CJ Thomas, Y Liu, YQ Zhang, A Rinderspacher, ... Bioorganic & medicinal chemistry letters 18 (1), 329-335, 2008 | 30 | 2008 |
| Comparison of miniaturized time-resolved fluorescence resonance energy transfer and enzyme-coupled luciferase high-throughput screening assays to discover inhibitors of Rho … T Schröter, D Minond, A Weiser, C Dao, J Habel, T Spicer, P Chase, ... SLAS Discovery 13 (1), 17-28, 2008 | 53 | 2008 |
| COMP 483-Random forest ensembles applied to MLSCN screening data for toxicity prediction and feature selection R Guha, S Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 234, 2007 | 2007 | |
| Prospective exploration of synthetically feasible, medicinally relevant chemical space SC Schürer, P Tyagi, SM Muskal Journal of chemical information and modeling 45 (2), 239-248, 2005 | 35 | 2005 |
| Relating chemical and biological space: An in-silico platform technology approach to accelerate the discovery of novel medicinally relevant small molecules. SC Schurer ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY 227, U679-U679, 2004 | 2004 | |
| Assay Guidance Manual KE Garbison, BA Heinz, ME Lajiness, JR Weidner, GS Sittampalam Eli Lilly & Company and the National Center for Advancing Translational Sciences, 2004 | 21 | 2004 |
| Separation of matching and mapping in chemical reaction transforms S Schurer, S Muskal, S Jha, P Tyagi US Patent App. 10/373,580, 2003 | 4 | 2003 |
| Separation of matching and mapping in chemical reaction transforms S Schurer, S Muskal, S Jha, P Tyagi US Patent App. 10/373,580, 2003 | 4 | 2003 |
| Method of flexibly generating diverse reaction chemistries B Bunin, T Powers, G Morales, S Schurer, S Muskal, O Saunders US Patent App. 10/300,730, 2003 | 2 | 2003 |
| Chemistry resource database B Bunin, S Schurer, S Muskal US Patent App. 09/996,635, 2002 | 8 | 2002 |
| Chemistry resource database B Bunin US Patent App. 09/825,135, 2002 | 47 | 2002 |
| Synthese und Anwendung eines permanent immobilisierten Olefinmetathese‐Katalysators SC Schürer, S Gessler, N Buschmann, S Blechert Angewandte Chemie 112 (21), 4062-4065, 2000 | 89 | 2000 |
| Synthesis and Application of a Permanently Immobilized Olefin‐Metathesis Catalyst SC Schürer, S Gessler, N Buschmann, S Blechert Angewandte Chemie International Edition 39 (21), 3898-3901, 2000 | 260 | 2000 |
| Beiträge zur Weiterentwicklung der Olefinmetathese SC Schürer Technische Universität Berlin, Universitätsbibliothek (Diss.-Stelle), 2000 | 2000 | |
| Beiträge zur Weiterentwicklung der Olefinmetathese: kombinatorische Synthese und neue Katalysatoren SC Schürer Berlin, Techn. Univ., Diss., 2000, 2000 | 2000 | |
| Sequences of yne-ene cross metathesis and Diels-Alder cycloaddition reactions-modular solid phase synthesis of substituted octahydrobenzazepinones SC Schürer, S Blechert Synlett 1999 (12), 1879-1882, 1999 | 19 | 1999 |
| Preparation of enantioenriched α-bromo acids incorporating diverse functionality AJ Souers, S Schürer, H Kwack, AA Virgilio, JA Ellman Synthesis 1999 (04), 583-585, 1999 | 26 | 1999 |
| A versatile synthesis of substituted tetrahydropyridines SC Schürer, S Blechert Tetrahedron letters 40 (10), 1877-1880, 1999 | 80 | 1999 |
| Short Papers-Preparation of Enantioenriched a-Bromo Acids Incorporating Diverse Functionality AJ Souers, S Schurer, H Kwack, AA Virgilio, JA Ellman Synthesis-Journal of Synthetic Organic Chemistry, 583-585, 1999 | 1999 | |
| Synthesis of pseudo-oligosaccharides by a sequence of yne-ene cross metathesis and Diels–Alder reaction SC Schürer, S Blechert Chemical Communications, 1203-1204, 1999 | 38 | 1999 |
| Novel inhibitors of α4β1 integrin receptor interactions through library synthesis and screening AJ Souers, AA Virgilio, SS Schürer, JA Ellman, TP Kogan, HE West, ... Bioorganic & medicinal chemistry letters 8 (17), 2297-2302, 1998 | 73 | 1998 |
| Ruthenium-Catalyzed Yne-Ene Cross Metathesis Binding to Solid Support and Cleavage by Pd0-Catalysis SC Schürer, S Blechert Synlett 1998 (02), 166-168, 1998 | 26 | 1998 |
| Expedient solid-phase synthesis of putative β-turn mimetics incorporating the i+ 1, i+ 2, and i+ 3 sidechains AA Virgilio, SC Schürer, JA Ellman Tetrahedron letters 37 (39), 6961-6964, 1996 | 102 | 1996 |
| Adaptation of a ß-turn Mimetic Synthesis Sequence to Enable the Rapid and Simultaneous Synthesis of Numerous Derivatives S Schürer | 1996 | |
| Supplemental Results M Pilarczyk, M Fazel-Najafabadi, M Kouril, B Shamsaei, J Vasiliauskas, ... | ||
| Large-scale Computational Screening Identifies First in Class Multitarget Inhibitor of EGFR Kinase and BRD4 N Ayad, SC Schürer | ||
| Connecting omics signatures of diseases, drugs, and mechanisms of actions with iLINCS F Reichard, V Stathias, A Koleti, D Vidovic, DJB Clark, S Schurer, ... | ||
| Kinome-wide Activity Models from Diverse High-Quality Datasets SC Schürer, SM Muskal | ||
| Supplementary Material Identification of a novel class of BRD4 inhibitors by computational screening and binding simulations BK Allen, S Mehta, SWJ Ember, JY Zhu, E Schönbrunn, NG Ayad, ... | ||
| Full wwPDB X-ray Structure Validation Report i○ Y Hai, JE Edwards, MC Van Zandt, KF Hoffmann, DW Christianson | ||
| Small Molecule-Mediated Activation of the Integrin CD11b/CD18 Reduces AN Donnelly, LF Moita, S Schürer, D Traver, P Ruiz, DH Balla, CJ Barth, ... | ||
| BAOSearch: A Semantic Web Application for Biological Screening and Drug Discovery Research UV Venkatapuram, S Schürer |